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The Painkillers during pregnancy could affect the fertility of the unborn child in the later life

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Painkillers during pregnancy could affect

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The Painkillers during pregnancy could affect the fertility of the unborn child in the later life

Painkillers during pregnancy could affect

Taking of painkillers during pregnancy can affect the fertility of the unborn child in later life, new research suggesting.

The Edinburgh University found the drugs may also affect the fertility of future generations, by leaving marks on the DNA.

Experts say the findings are adding to growing evidence some medicines, including Paracetamol, should be used with caution during pregnancy.

The Researchers stressing advice for pregnant women remain unchanging.

Current guidelines say, if necessary, Paracetamol should use at the lowest possible dose for the shortest possible time. Ibuprofen should be avoided during the pregnancy.

The study is looking at the effects of Paracetamol and ibuprofen on the samples of human fetal testes and ovaries.

The Tissue samples

The scientists found similar effects using several different experimental approaches, including lab tests on the human tissue samples and animal studies.

Human tissue exposing to either drug for one week in a dish has reduced numbers of germ cells that giving rise to sperm and eggs, cells, the study found.

Ovaries exposing to Paracetamol for one week has more than 40% fewer egg-producing cells.  Ibuprofen exposure is the number of cells was almost halving.

Experts say this was important because girls produce all of their eggs in the womb, so if they are born with a reducing number, it can lead to early menopause.

The Painkiller exposure during development could have effects on the unborn boys too, the study finds.

Testicular tissue exposing to painkillers in a culture dish has around a quarter fewer sperm-producing cells after exposure to Paracetamol or ibuprofen.

The team is also testing the effects of painkiller treatment on mice that carried grafts of human fetal testicular tissue.

The grafts have been shown to mimic how the testes grow and function during development in the womb.

The Female offspring

After in just one day of treatment with the human-equivalent dose of Paracetamol, number of the sperm-producing cells in graft tissue had dropped by 17%. After a week of drug treatment, there is the 1/3rd third fewer cell.

Previous studies with the rats have shown that painkillers administering in pregnancy led to a reduction in germ cells in female offspring.

It affected their fertility and the fertility of females in subsequent generations.

The scientists found that exposure to Paracetamol or ibuprofen triggered mechanisms in the cell that made changes in the structure of DNA, called is known as epigenetic marks.

The marks can be inherited, helping to explain how the effects of painkillers on fertility may be passed on to future generations.

Painkillers’ effects on germ cells are likely causing by their actions on molecules called prostaglandins, which have critical functions in the ovaries and testes, the researchers found.

The study, published in Environmental Health Perspectives, was funded by the Medical Research Council, Welcome British Society of the Paediatric Endocrinology and Diabetes.

Dr. Rod Mitchell, who is letting the research at the University of Edinburgh’s MRC Centre for Reproductive Health, says “We will encourage women to think carefully before taking painkillers in pregnancy and to following existing guidelines that are taking a lowest possible dose for the shortest time possible.”

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